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Targeting the seed and the soil of myelomagenesis

The objective of the EU-FP7 research consortium OPTATIO is to exploit the importance of interactions between multiple myeloma cells and the bone marrow microenvironment. These interactions play a vital role in the survival of tumour cells, the development of drug resistance and the progression of the disease. OPTATIO's aim is to develop  principally new and innovative multiple myeloma treatment strategies by targeting not only the "seed", but also the "soil" of myelomagenesis, searching for compounds that have the capacity to interfere with this complex biological network.

(Foto: Otto Kahler)