Workpackages Tolerage

Workpackage Area 1 - Mechanisms of central and peripheral tolerance
WP1	T-cell selection: The role of intrathymic autoantigen expression
WP2	Thymic involution: The role of locally produced glucocorticoid hormones
WP3	Teffector/Tregulatory imbalance with increasing age
WP4	The role of dendritic cells in tolerance induction
WP5	The role of dendritic cells in antigen presentation
WP6	Generation of regulatory dendritic cells in vitro using glucocorticoid hormones
WP7	Age dependent changes of the cytokine balance

Workpackage Area 2 - Paradigmatic diseases of aging - rheumatoid arthritis and atherosclerosis
WP8	Rheumatoid arthritis
WP9	Atherosclerosis

Workpackage Area 3 - Therapy by induced tolerance
WP10	Induction of immunologic tolerisation to autoantigens
WP11	Mechanisms of tolerance induction
WP12	Manipulation of locally produced glucocorticoids to delay thymic involution as therapy in models for autoimmunity

Workpackage Area 4 - Management
WP13	Management